Flavonoids – MPFF Diosmin, Hesperidin & Horse Chestnut Extract
Natural support for vein health and circulation
At PureLife Nutrition, we believe that the effectiveness of supplements begins with the quality of their ingredients. Our formulas, based on diosmin, hesperidin, and horse chestnut extract (aescin), support:
- healthy circulation and leg comfort,
- reduction of heaviness and swelling,
- natural inflammatory balance,
- vitality at work, during travel, and in everyday life.
Convenience and savings — automatic monthly delivery with a 10% discount.
Why choose Flavonoids by PureLife Nutrition?
Our micronized Flavonoids are a premium-class supplement created with purity and safety in mind. Manufactured in accordance with the highest GMP standards (FDA-approved) and based on ISO 22000 / HACCP systems, they ensure complete quality control at every stage.
✔ Suitable for vegans and those on a gluten-free diet
✔ Laboratory-tested, free from artificial colors and additives
✔ Pure active ingredients – diosmin, hesperidin, and horse chestnut
✔ No talc, gelatin, or allergens
By choosing PureLife Nutrition, you choose safety, transparency, and effectiveness backed by certified quality standards.
| Feature | PureLife Venalex | Other supplements |
|---|---|---|
| Active ingredients | Diosmin 150 mg + Hesperidin 150 mg + Horse Chestnut 150 mg | Lower or unclear dosages |
| Technology | MPFF – Micronized Purified Flavonoid Fraction | Standard powder form |
| Circulation & veins | ✅ Supports healthy blood flow and vessel strength | ❌ Limited support |
| Lymphatic drainage | ✅ Yes | ❌ Usually not included |
| Inflammatory response | ✅ Natural support for the body | ❌ Often overlooked |
| Quality & certifications | EU GMP, ISO, HACCP | No certifications |
| Transparency | Independent COA testing | No data provided |
| Lifestyle compatibility | Vegan, gluten-free, lactose-free | Often contains fillers |
Why is it worth it?

Studies show that 80% of people aged 35 to 70 suffer from varicose veins or telangiectasia.
✨ Did you know that…
You can support the health of your legs with flavonoids and regular exercise:
🍊 Flavonoids (found in citrus fruits, berries, tea, and dark chocolate) help improve vein tone, reduce inflammation, and support better circulation.
🏃 Leg exercises such as walking, cycling, calf raises, and stretching improve blood flow, strengthen the muscles that support venous function, and can help relieve heaviness or swelling.
👉 Combine a flavonoid-rich diet with daily leg activity to protect vein health and keep your legs lighter and stronger after the age of 35.
💚 Small lifestyle changes can have a big impact on circulation!
Micronized diosmin and hesperidin combined with horse chestnut extract (aescin).
Supports blood flow, vascular elasticity, and natural lymphatic drainage.
Helps maintain balance in the body’s inflammatory response.
What people using Flavonoids say
About the benefits of Flavonoids — Harvard, Cambridge, NIH, PubMed
Frequently Asked Questions (FAQ)
What is the difference between micronized Diosmin and regular Diosmin?
Micronization increases the bioavailability and absorption of active substances, improving their effectiveness.
Can the product be used daily?
Yes, the supplement is intended for daily use to support circulation and leg comfort.
Are Flavonoids vegan and gluten-free?
Yes, the product is 100% vegan, gluten-free, and lactose-free.
What is aescin used for?
Aescin (also known as escin) is a mixture of saponins extracted from horse chestnut seeds (Aesculus hippocastanum) primarily used to improve blood circulation, particularly in the veins, and to treat swelling (edema) and inflammation. It is often used to treat chronic venous insufficiency (CVI), varicose veins, hemorrhoids, and to reduce swelling after surgery or injury.
Primary Uses and Benefits
Chronic Venous Insufficiency (CVI): Aescin increases vein tone, reducing the inability of veins to send blood back to the heart, which causes heavy, swollen, and painful legs.
Anti-Edema (Swelling Reduction): It reduces the permeability of capillaries, preventing fluid from leaking into surrounding tissues, which is highly effective for reducing edema.
Post-Traumatic/Post-Surgical Swelling: It helps reduce swelling and bruising (hematomas) resulting from injuries, fractures, and surgery (e.g., dental or aesthetic procedures).
Varicose Veins and Hemorrhoids: By increasing venous tone and protecting blood vessels, it helps alleviate symptoms of varicosity and hemorrhoidal disease.
Microcirculation Enhancement: It improves blood flow in tiny blood vessels, which is useful in managing diabetic microangiopathy and preventing ulceration.
Key Pharmacological Mechanisms
Anti-inflammatory: Aescin inhibits inflammatory enzymes (elastase, hyaluronidase), reducing inflammatory mediators and protecting vessel walls.
Venotonic (Vein Strengthening): It improves venous tone by enhancing the constriction action of noradrenaline.
Antioxidant: It protects blood vessel walls from free radical damage.
Key Considerations
Side Effects: While generally well-tolerated, side effects can include gastrointestinal discomfort (nausea, diarrhea), headache, and dizziness.
Warnings: It should not be used if you have severe renal (kidney) impairment or if you are pregnant/breastfeeding. It may interact with anticoagulants (“blood thinners”).
Horse chestnut seed extract
Horse chestnut seed extract is primarily used to treat chronic venous insufficiency (CVI), a condition causing poor circulation, varicose veins, leg swelling, pain, and itching. Its active compound, aescin, strengthens vein walls, reduces inflammation, and acts as an anti-edema agent.
Key Uses and Benefits:
Chronic Venous Insufficiency (CVI): Significantly reduces symptoms like leg pain, heaviness, and swelling, with efficacy similar to compression stockings.
Varicose Veins & Hemorrhoids: Often used to improve blood circulation and treat venous swelling.
Anti-inflammatory and Swelling: Applied to reduce swelling, treat sports injuries, trauma, and bruising.
Other Potential Uses: Researched for alleviating symptoms of hemorrhoids, Irritable Bowel Syndrome (IBS), and male infertility related to varicocele.
Cosmetics: Used in topical creams to manage skin redness, improve lymphatic drainage, and reduce the appearance of cellulite.
Flavonoids by PureLife NUTRITION vs other products
GMP and ISO Quality MPFF suitable for vegans, gluten free.
No titanium dioxide
EU pharmaceutical-grade
higher absorption MPFF
What is May-Thurner Syndrome?
Left-side varicose veins are common, often caused by increased venous pressure, chronic venous insufficiency, or structural issues like May-Thurner Syndrome, where the left iliac vein is compressed. Symptoms include heavy, aching legs, visible bulging, swelling, and potential skin changes. Treatment includes compression stockings, elevation, and minimally invasive procedures.
Key Considerations for Left Leg Varicose Veins
Anatomical Factors: The left side is often more affected because the left iliac vein crosses under the right iliac artery, leading to higher rates of compression, known as May-Thurner Syndrome.
Symptoms: Left leg swelling, pain, aching, and, in severe cases, deep vein thrombosis (DVT).
Causes: Weakened or damaged vein valves, chronic venous insufficiency, pregnancy, or prolonged standing.
Diagnosis & Management: A vascular specialist (phlebologist) can diagnose the condition using ultrasound. Initial management includes conservative measures like wearing compression stockings.
Treatment Options: If necessary, procedures such as sclerotherapy, endovenous laser therapy (EVLT), or in the case of May-Thurner, stenting, can be used to treat the underlying issue.
Lift your legs up bnefits.
Leg lift exercises and elevating the legs provide significant benefits for both strength and recovery. They strengthen the lower abdominals, hip flexors, and core, while passive elevation (legs-up-the-wall) improves circulation, reduces leg swelling, relieves lower back tension, and promotes relaxation by triggering the parasympathetic nervous system.
Key Benefits of Active Leg Lifts (Exercise)
Core Strength: Primarily targets the lower rectus abdominis and hip flexors for a stronger core.
Lower Back Health: Strengthens the lower back, increasing stability.
Improved Posture & Stability: Enhances overall balance and core stability.
Hip Arthritis Pain Relief: Helps strengthen the muscles surrounding the hip joint, reducing pain.
Increased Flexibility: Helps stretch the hamstrings and lower back.
Key Benefits of Passive Leg Elevation (Yoga Pose/Rest)
Reduced Swelling and Fluid Retention: Promotes venous drainage, helping to reduce edema (swelling) in the feet, ankles, and legs, according to this Times of India article.
Relieves Lower Back Pain: Helps relax tight muscles in the lower back and pelvic floor.
Improves Circulation: Helps reverse the effects of gravity, promoting blood flow toward the upper body and heart.
Promotes Relaxation: Stimulates the vagus nerve and aids in stress reduction.
Faster Recovery: Relieves tired legs and reduces muscle fatigue, especially after long periods of sitting or standing.
How to Perform “Legs Up the Wall” (Passive)
Sit with one hip against a wall.
Gently lie back and swing your legs up the wall simultaneously.
Ensure your back is flat on the floor and your hips are comfortable.
Relax for 5–20 minutes.
Flavonoids by PureLife NUTRITION
Healthy legs with Flavonoids.
MPFF REDUCES BLEEDING
The MPFF line drops sharply, showing a strong reduction in bleeding over time
The placebo line also decreases, but much more gradually
Clinical studies show MPFF reduces hemorrhoidal bleeding by up to 90% within a week compared to placebo.
Where I can find more information about Flavonoids ?
If you would like to know more about Flavonoids in Harvard, Cambridge, NIH, PubMed medical Press:
1. About Flavonoids in Harvard Medical School- These plant chemicals, found in most fruits and vegetables, may play an important role in cognitive fitness and dementia prevention. link
https://www.health.harvard.edu/mind-and-mood/the-thinking-on-flavonoids
2. Role of flavonoids and nitrates in cardiovascular health in Cambridge Medical Press https://www.cambridge.org/core/journals/proceedings-of-the-nutrition-society/article/role-of-flavonoids-and-nitrates-in-cardiovascular-health/1E3DA29D3679556826E9F0D38DB2D478
3. Flavonoids associated with better erectile function https://www.health.harvard.edu/mens-health/in-the-journals-flavonoids-associated-with-better-erectile-function
4. Flavonoid antioxidants- https://pubmed.ncbi.nlm.nih.gov/11375750/
5. Flavonoids as Anticancer Agents https://pubmed.ncbi.nlm.nih.gov/32059369/
6. Dietary Flavonoid Intake and Chronic Sensory Conditions: A Scoping Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311508/
7. Does Flavonoid Consumption Improve Exercise Performance? Is It Related to Changes in the Immune System and Inflammatory Biomarkers? A Systematic Review of Clinical Studies since 2005 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065858/
8. Neuroprotective Potential of Flavonoids in Brain Disorders https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526484/
9. The Effects of Flavonoids on Cardiovascular Health: A Review of Human Intervention Trials and Implications for Cerebrovascular Function https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315948/
10. Flavonoids as Anticancer Agents https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071196/
What are the best exercise for healthy legs as second heart ?
The best exercises to activate your “second heart”—the calf muscles—focus on engaging the lower legs to pump blood upward, enhancing circulation and reducing swelling. The top exercises include calf raises (standing or seated), brisk walking, stair climbing, hiking, and ankle pumps. Daily, consistent movement is more effective than occasional, intense workouts.
Key Exercises for Healthy Legs (“Second Heart”)
Calf Raises (Most Effective): Rise onto your toes and lower slowly to engage calf muscles, performing 3 sets of 15–20 reps.
Brisk Walking: A daily 30-minute walk significantly boosts calf muscle function and vein health.
Stair Climbing/Hiking: Using stairs or hiking offers natural resistance, strengthening calves more than flat walking.
Ankle Pumps/Circles: While sitting, point and flex your feet to stimulate circulation, particularly useful during long periods of sitting.
Skipping/Jumping Rope: Provides a high-intensity option to strengthen calf muscles and improve cardiovascular endurance.
Czy mamy drugie serce w naszym organiźmie ?
Tak, mięśnie nóg uważane są za “drugie serce”. Szczególną rolę w krążeniu krwi odrywają mięśnie brzuchaty łydki, a dokładniej mięsień płaszczkowaty łydki i to właśnie ten mięsień nazywany jest naszym drugim sercem. Poprzez stosowanie prostego ćwiczenia- wspięcie na palce, możemy skutecznie wypompować krew zalegającą w nogach. To proste ćwiczenie jakim jest wspięcie na palce, możesz robić stojąc lub siedząc np. w pracy. Włókna czerwone, czyli wolnokurczliwe wymagają co najmniej 20 powtórzeń.
Should I choose stairs or elevator? Healthy life habit- always choose stairs.
Choosing to take the stairs instead of the elevator is a highly effective, free, and accessible “habit hack” that significantly improves cardiovascular health, strengthens muscles, and boosts longevity. Studies show that climbing more than five flights of stairs (approx. 50 steps) daily can reduce the risk of heart disease by up to 20%.
How should i train my second heart stairs ?
Training your “second heart”—the calf muscles—using stairs is one of the most effective ways to boost circulation, reduce leg swelling, and improve cardiovascular health by helping pump blood back up to the heart.
Here is how to train your second heart on the stairs:
Key Stair Exercises for Your Second Heart
Stair Calf Raises/Heel Drops: Stand with the balls of your feet on the edge of a step, holding a railing for balance. Slowly raise your heels as high as possible, hold for 2–3 seconds, then lower your heels below the level of the step to get a full stretch. Perform 15–20 reps, 2–3 sets.
Single-Leg Calf Raises: For increased difficulty, do the above exercises on one leg at a time.
Step-Ups: Step up onto a step with one leg, pushing through the heel, and bring the other foot up. Step back down slowly. Perform 10–12 reps per leg.
Side Steps: Stand with your right side parallel to the stairs. Step your right foot up, followed by your left. Continue up the stairs, always leading with the high foot.
Routine Recommendations
Consistency: Aim for 2–3 sessions per week.
Daily Maintenance: Take a 3-minute stroll up and down the stairs after a meal to help boost circulation and manage blood sugar.
Tips for Success
Railing Usage: Use the railing for stability, particularly if you are a beginner or have balance issues.
Slow Down: The benefit comes from the slow, controlled movement, not just speed.
Don’t Forget the Stretch: Stretching the calf muscles after the workout is crucial for maintaining functionality.
Are Flavonoids- diosmin, hesperidin horse chestnut for runners good ?
Yes, flavonoids like diosmin and hesperidin combined with horse chestnut are generally considered good for runners. They enhance venous tone, improve microcirculation, and reduce inflammation, which helps alleviate heavy/swollen legs and speeds recovery. These compounds strengthen capillaries and provide vascular support, aiding in the reduction of exercise-induced edema.
Benefits for Runners
Reduced Leg Heaviness/Swelling: Diosmin and hesperidin (often used as MPFF) reduce capillary permeability, reducing edema (swelling) and improving leg comfort.
Faster Recovery & Reduced Inflammation: Horse chestnut contains aescin, which has powerful antiphlogistic (anti-inflammatory) properties, aiding in reducing muscle strain and swelling.
Improved Endurance & Performance: Hesperidin acts as an ergogenic aid, enhancing endothelial function (nitric oxide availability), which improves anaerobic power and energy.
Vascular Protection: These ingredients protect capillaries and improve blood flow, crucial for managing the intense stress placed on lower limb vessels during running.
Key Considerations
Effectiveness: Studies show these agents improve vein health, reduce pain, and reduce calf/foot circumference.
Components: Micronized purified flavonoid fraction (MPFF—Diosmin and Hesperidin) along with horse chestnut is a common, effective combination for strengthening veins.
Safety: They are generally well-tolerated, but diosmin can occasionally cause digestive issues.
Gdzie kupisz oryginaly Flavonoids od PureLife NUTRITION ?
Oryginalny Flavonoids możesz kupić na Allegro, Amazon oraz w aptekach w Poznaniu, Kołobrzegu. Zapraszamy do współpracy wszystkich ceniących sobie najwyższą jakość od PureLife NUTRITION.
Link do oferty na Allegro https://allegro.pl/oferta/flavonoids-mpff-diosmina-hesperydyna-kasztanowiec-60-kapsulek-ciezkie-nogi-18577690918
Link do oferty na Amazon https://www.amazon.pl/Flawonoidy-mikronizowana-hesperydyna-kasztanowiec-bezglutenowa/dp/B0C4Y57ZPX

















